Chapter 3 ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions Abstract CYP酶CYP2B6, CYP2C9, CYP2C19, and CYP2D6和转运体 ABCB1 and OAT1B1具有genetic polymorphisms, 约占人群的1% 3.1 Introduction pharmacogenetics的关注重点已由最开始的药物代谢酶(M),扩展到影响ADE的膜转运体 Genetic variants not only determine to which extent a drug is metabolized, taken up or excreted by ADME genes,[…]↓ Read the rest of this entry…