The first Finnigan LCQ MS I used.
The first Finnigan LCQ MS of Prof. Zhong’s lab@SYPU

Yufeng  Zhang, Ph.D.
School of Pharmacy,
Chinese University of Hong Kong
Email: zhangyufeng+msky(at)


  • Global Drug information Knowledge Database.
  • Mechanic Modeling of in vitro and in vivo Processes

Ph.D., Pharmaceutical Analysis, Zhejiang University, 2008
M.S., Pharmaceutical Analysis, Shenyang Pharmaceutical University, 2004
B.S., Pharmacy, Shenyang Pharmaceutical University, 2001

2013-now, Research Associate, CUHK, Hong Kong
2012-2013, Associate Research Professor, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou
2012.7-10, Visiting Scholar, School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
2010-2011, Assistant Professor, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou
2008-2010, Postdoctoral research in Metabolism & Pharmacokinetics of Traditional Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou


  1. Zhang YF, Liu H, Tang MH, Ho Nicholas James, Shek TL, Yang ZJ, Zuo Z. (2021) Screening of bioequivalent extended-release formulations for metformin by principal component analysis and convolution-based IVIVC approach. AAPS Journal, accepted.
  2. Zhao JJ, Cheng SW, Ng WL, Zhang YF, Shek TL, Ren TJ, Yan XY, Li K, Wang JX, Zuo Z* (2020). Identification of the In-Vivo Relevant Dissolution Media for the Three Active Components in EGb 761 Tablet for Better Correlation with Their Pharmacokinetics in Healthy Subjects. European Journal of Pharmaceutical Sciences, 154:105515.
  3. Zhang YF, Yang MB, Ho NJ, Mok RY, Zhang Z, Ge BK, Leung PC, Fung KP, Lau BSC, Lee HLV, Lin ZX, Wong SMR, Zuo Z* (2020). Is It Safe to Take Radix Salvia Miltiorrhiza–Radix Pueraria Lobate Product with Warfarin and Aspirin? A Pilot Study in Healthy Human Subjects. Journal of Ethnopharmacology, (262):113151.
  4. Zhang YF, Lyu CM, Fong SYK, Wang QW, Li CR, Ho NJ, Chan KS, Yan XY, Zuo Z* (2019). Evaluation of Potential Herb-Drug Interactions Between Oseltamivir and Commonly Used Anti-Influenza Chinese Medicinal Herbs. Journal of Ethnopharmacology. 243:112097.
  5. Wang QW, Zhang YF, Wong CH, Edwin Chan HY, Zuo Z* (2017). Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling. The AAPS Journal, 20(1):23.
  6. Lyu CM, Zhang YF, Zhou WB, Zhang S, Kou F, Wei H*, Zhang N*, Zuo Z* (2016). Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence. The AAPS Journal,18(2):432-444.
  7. Zhang YF, Wang XA, Wo SK, Ho HM, Han QB, Fan HX, Zuo Z* (2015). Novel Algorithm for Simultaneous Component Detection and Pseudo-Molecular Ion Characterization in Liquid Chromatography-Mass Spectrometry. Analytical Chimica Acta, 853:402-414.
  8. Gao Q, Zhang YF, Wo SK, Zhong Z. Extensive intestinal first-pass metabolism of arctigenin: Evidenced by simultaneous monitoring of both parent drug and its major metabolites. Journal of Pharmaceutical and Biomedical Analysis, 2014, 91: 60-67.
  9. Zhang YF, Xiao S, Sun LJ, Ge ZW, Fang FK, Zhang W, Wang Y, Cheng. YY. Rapid screening of bioactive compounds from natural products by integrating 5-channel parallel chromatography coupled with on-line mass spectrometry and microplate-based assays. Analytica Chimica Acta, 2013, 777: 49-56.
  10. Gao Q, Zhang YF, Wo SK, Zhong Z. Hydrolysis Is the Dominating In Vivo Metabolism Pathway for Arctigenin: Identification of Novel Metabolites of Arctigenin by LC/MS/MS after Oral Administration in Rats. Planta Medica, 2013, 79: 471-479.
  11. Xiao S, Qian S, Wang Y, Zhang YF*, Cheng YY. Compound Coverage Enhancement of Electrospray Ionization Mass Spectrometry through the Addition of a Homemade Needle. Analyst, 2013, 138:1772. DOI:10.1039/C2AN36656H.
  12. Zhang YF, Xiao GD, Sun LJ, Wang YC, Wang Y, Wang Y. A new flavan-3-ol lactone and other constituents from Euonymus alatus with inhibitory activities on α-glucosidase and differentiation of 3T3-L1 cells, Natural Product Research, 2013, 27(17): 1513-20. DOI: 10.1080/14786419.2012.725400.


  1. Zhang YF, Xiao GD, Sun LJ, Wang YC, Wang Y, Wang Y. A new flavan-3-ol lactone and other constituents from Euonymus alatus with inhibitory activities on α-glucosidase and differentiation of 3T3-L1 cells, Natural Product Research, 2012, in press.
  2. Zhang YF, Pan JY, Zhong JH, Wang Y, Fan XH, Cheng YY. Virtual separation of phytochemical constituents by their adduct-ion patterns in full mass spectra, Journal of Chromatography A, 2012, 1227: 181-193.
  3. Zhang YF, Xiao S, Li Xiong, Zeng X, Wang Y. Ionization of shikonin derivatives using negative-ion electrospray mass spectrometry: [M-H] versus [M+e]Ÿ, Journal of Mass Spectrometry, 2012, 47, 581-585.
  4. Zhang YF, Shi PY, Yao H, Shao Q, Fan XH: Metabolite profiling and Pharmacokinetics of Herbal Compounds Following Oral Administration of a Cardiovascular Multi-herb Medicine (Qishen Yiqi Pills) in rat. Current Drug Metabolism, 2012, 13, 510-523.
  5. Tao Y, Jiang W, Cheng YY, Zhang YF*. Two new compounds from Senecio cannabifolius. Journal of Asian Natural Products Research, 2012, DOI:10.1080/10286020.2012.697456.
  6. Yang ZZ, Wang YC, Wang Y, Zhang YF*: Bioassay-guided screening and isolation of α-glucosidase and tyrosinase inhibitors from leaves of Morus alba. Food Chemistry, 2012, 131, 617-625.
  7. Zhang YF, Pan JY, Wang J, Shao Q: Pharmacokinetics of ginsenosides Rg1, Re and notoginsenoside R1 in rats by an in vivo microdialysis coupled with liquid chromatography/mass spectrometry. Asian Journal of Chemistry, 2012, 24(1):273-277.


  1. Zhao XP, Jin YC, Zeng X, Zhang BL, Zhang YF*: Screening and Identifying of Nephrotoxic Compounds in Lithospermum erythrorhizon Using Live-cell Fluorescence Imaging and Liquid Chromatography Coupled with Tandem Mass Spectrometry. Chem Res Chinese U, 2011, 27(4):562-565.
  2. Zhang YF, Zhao QQ, Shao Q, Fan XH: Simultaneous Determination of Two Types of Active Components with Different Physicochemical Properties in Kushen by HPLC-UV. Chem Res Chinese U, 2011, 27(3):375-379.
  3. Zhang YF, Fan XH, Qu HB: A Novel Approach for Quality Evaluation of TCM based on Integrated Selected-Ion Chromatograms. Chemical Journal of Chinese Universities, 2011, 32(11):2515-2520.
  4. Li X, Zhang YF, Zeng X, Deng YH, Yang L: Chemical profiling of bioactive constituents in Sarcandra glabra and its preparations using ultra-high-pressure liquid chromatography coupled with LTQ Orbitrap mass spectrometry. Rapid Commun Mass Sp, 2011, 25(17):2439-2447.
  5. Li Q, Zhang YF, Wu B, Qu HB: Identification of indole alkaloids in Nauclea officinalis using high-performance liquid chromatography coupled with ion trap and time-of-flight mass spectrometry. Eur J Mass Spectrom, 2011, 17(3):277-286.
  6. Shi PY, Zhang YF, Qu HB, Fan XH. Systematic characterization of secondary metabolites from Ixeris sonchifolia by the combined use of HPLC-TOFMS and HPLC-ITMS. Phytochemical Analysis, 2011, 22, 66-73.
  7. Zhao QQ, Zhang YF, Fan XH. Simultaneous characterization of two types of major active components in Kushen by high performance liquid chromatography coupled to multi-stage \mass spectrometry. China Journal of Chinese Materia Medica, 2011, 36(6): 762-769.


  1. Zhang YF, Ma JF, Zhao QQ, Wu B, Zeng X. Chemical Characterization of Phenolic Compounds in Erigeron Injection by Rapid-Resolution Liquid Chromatography Coupled with Multi-stage and Quadrupole/Time-of-Flight Mass Spectrometry. Chromatographia, 2010, 72(7/8), 651-658.
  2. Wu B, Zeng X, Zhang YF*. New metabolite from Viburnum dilatatum. Natural Product Communications, 2010, 5(7), 1097-1098.
  3. Wang J, Zhang YF, Shao Q, Fan XH. Serum metabolome analysis reveals effect of panax notoginosides on ischemic rat after acute myocardial infarction. China Journal of Chinese Materia Medica, 2010, 35(23): 3199-3202.


  1. Zhang YF, Zhong JH, Fan XH, Guo Z, Wu JB, Zhang YY. A new HPLC method for the simultaneous determination of bioactive isoprenylated favonoids in a traditional Chinese medicine. Separation Science Asia Pacific, 2009, 1, (12), 3-13.
  2. Shi PY, He Q, Zhang YF, Qu HB, Cheng YY. Characterization and identification of isomeric dibenzocyclooctadiene lignans from Schisandra chinensis by high performance liquid chromatography combined with electrospray ionization tandem mass spectrometry. Phytochemical Analysis. 2009, 20, 197-206.


  1. Zhang YF, Zhang PY, Cheng YY. Structural characterization of isoprenylated flavonoids from Kushen by electrospray ionization multistage tandem mass spectrometry. J Mass Spectrom, 2008, 43, 1421-1431.
  2. Zhang YF, Wang ZY, Ma Z, Cheng YY. Characterization of Progesterone Derivatives by LC-DAD-ESI/MSn and Its Application to the Identification of Impurities in Flurogestone Acetate Chromatographia, 2008, 68, 903-909.


  1. Zhang YF, Shi PY, Qu HB, Cheng YY. Characterization of phenolic compounds in Erigeron breviscapus by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom, 2007, 21, 2971-2984.
  2. Zhang YF, Shi PY, Cheng YY. Study on the related substances of flugestone acetate. Chin. J. Pharm. Anal. 2007, 27(11), 1735-1737.


  1. Zhang YF, Shi QR, Shi PY, Zhang WD, Cheng YY. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin-Guo-Lan (Tinospora sagittata and Tinospora capillipes) by high-performance liquid chromatography/electrospray ionization with multistage mass spectrometry. Rapid Commun Mass Spectrom, 2006, 20, 2328-2342.
  2. Shi PY, Zhang YF, Shi QR, Zhang WD, Cheng YY. Quantitative Determination of Three Protoberberine Alkaloids in Jin-Guo-Lan by HPLC-DAD. Chromatographia, 2006, 64, 163-168.
  3. Xu H, Zhang Y, Sun Y, Zhang P, Chu F, Guo Z, Zhang H, Zhong D. Metabolism and excretion of imrecoxib in rat. Xenobiotica, 2006, 36, 441-55.

2005 and before

  1. Dong Y, Qiu F, Zhang YF, Zhong DF, Yan CY. Au unusual rearrangement process of neutral loss of CO2 in carbamates by electrospray ionization-multistage mass spectrometry. J. Chin. Mass Spectrom. Soc. 2005, 26(1), 6-9.
  2. Shi XG, Zhong DF, Sun YM, Zhang YF. Metabolites of a novel antibiotic bitespiramycin in rat urine and bile. Chin. Chem. Lett. 2004, 15, 431-434.
  3. Shi XG, Sun YM, Zhang YF, Zhong DF. Tissue distribution of bitespiramycin and spiramycin in rats. Acta Pharmacol Sin 2004, 25, 1396-1401.
  4. Zhang YF, Zeng YL, Xing J, Zhong DF. Determination of isomeric ingredients in potassium guaiacolsulfonate. Chin. J. Pharm. Anal. 2003, 23(5), 338-341.
  5. Zhang YF, Chen XY, Zhong DF. Rapid identification of the major metabolites of Imrecoxib in rat urine and feces by ESI ion trap mass spectrometry. J. Chin. Mass Spectrom. Soc. 2003, 24(Suppl.), 97-98.
2 thoughts on “About”
  1. I’m done ! This web site is the very best i came across in recent months, and so you will have another regular visitor to your site. Keep up the amazing work!

  2. 张老师您好:




    波长比较短,少了10~20 nm


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