Job Description
- School of Pharmacy at Chinese University of Hong Kong (CUHK) is offering TWO postdoc positions for 24 months.
- The project aims to study normal or disease related herb-drug interactions using PK modelling and artificial intelligent technologies.
- The project will be in collaboration with recognized experts from Department of Computer Science and Engineering, CUHK in the field of Big Data Analytics and Natural Language Processing.
- The candidates will have access to our close-source drug information databases and will be responsible for the development and evaluation of drug related models.
Job Qualifications
- A doctoral (Ph.D. or equivalent) degree in applied mathematics, engineering, (bio)statistics, pharmaceutical sciences, clinical pharmacology or a related life sciences field.
- Experience and proven skills in at least one programming language (R, Python, Perl, Java, et al).
- Experience with NONMEM would be an asset as well as familiarity with common modelling methodologies.
- A background in basic pharmacology, genetics, pharmacometrics, PBPK and/or systems pharmacology is considered beneficial.
- Candidates will be assessed for their ability to work as part of the team, communication skills, track record of publications and demonstrated motivation and passion.
To Apply
- Please send your letter of motivation and curriculum vitae electronically to Professor & Director ZUO Zhong, joanzuo@cuhk.edu.hk.
跨界混搭新名词
学科交叉老话题
跨界(crossover)和混搭(mix and match)是当前比较流行的新名词,尤其在其进入互联网以后,被一些大V、名嘴给吹的妇孺皆知,像我等躲在角落搞研究的人,也不能豁免。罗胖子罗歪嘴整天在微信上宣扬下一代的商业模式,其核心就是通过跨界来寻找新的商机,他疯狂的把房子都卖了,以显示其对新的互联网模式的支持。每个人自有其精彩的生活方式,这不是我们关注的重点,只是其提到的跨界概念,在我们药学领域也广泛存在,今天我们就来谈谈药学领域的跨界问题。不过,在药学领域,这个不叫跨界,也不叫混搭,一般称为“学科交叉(inter-discipline)”,可以是用一个学科的技术解决另一个学科的问题,也可以是一个学科的思想启发另一个学科。本质来讲,药学就是学科交叉而来的,比如药物学与化学、物理、计算机等学科的交叉,产生了药物化学、药物分析学、药剂学、药物动力学,药物计量学等,目前,一些新出现的研究领域,更是学科交叉的典范,比如各种组学、网络药理学、计算毒理等。
一锅中药惹人愁
寻得关键才无忧
前文讲到由于质谱自身关于化合物精细结构的信息有限,需借助已有标准物质建立裂解规律,才能对同类物质的未知结构进行推断。除了借助标准品的信息,中药中成分间自有的关联信息也非常有用。中药(包括药材和方剂),甚至植物药,中的成分间往往存在某种特定的关系,很少遇到仅是孤零零几个不相关成分的情况,这个特点特别适合于用质谱分析,并且鉴定的时候,不出结果则已,一出结果那就是一大串化合物同时被鉴定了。因此,找到这个一锅粥中的内在联系,将会使我们的质谱分析工作事半功倍。
多少解谱心酸事
都付一三笑谈中
这个坑挖的太久了,好久没填了,真是不好意思!那今天就来点ESI质谱解析中最关键的猛料,可以这么说吧,只要掌握这一点,就掌握了质谱解析的百分之八十以上,其他的就靠自己回去偷着演练了。今天的内容相当于武功里面的“九阴真经”和“葵花宝典”!不过不需要自宫哦~
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