MS Blog of Dr. Zhang

学过药动的人都知道生物利用度（F）是一个非常重要的参数，其反映了机体对药物的利用程度。Wikipedia上对生物利用度（Absolute bioavailability）的解释为：

In pharmacology, in order to determine absolute bioavailability of a drug, a pharmacokinetic study must be done to obtain a plasma drug concentration vs time plot for the drug after both intravenous (iv) and extravascular (non-intravenous, i.e., oral) administration. The absolute bioavailability is the dose-corrected area under curve (AUC) non-intravenous divided by AUC intravenous. For example, the formula for calculating F for a drug administered by the oral route (po) is given below.

那个这个生物利用度F是否可以认为是当药物口服的时候，进入体内的药物的百分比呢？即当生物利用度为10%，给药剂量为100mg时，那么进入体内的总药物量就是10mg。

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